儿童自主神经系统异常炎症性肠病和刺激性肠综合征:一项比较研究
Paola Ruška1, Antonella Jerković1, Sara Sila1
1Department of Pediatrics, Children's Hospital Zagreb, Zagreb, Croatia.
概括
患有刺激性肠综合征 (IBS) 和炎症性肠病 (IBD) 的儿童表现出自主神经系统 (ANS) 异常. IBS患者表现出更高的症状负担,而IBD患者有更大的运动功能障碍,影响生活质量.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 自主神经科学 自主神经科学
- 临床医学 临床医学
背景情况:
- 自主神经系统 (ANS) 功能障碍在儿科胃肠道疾病中越来越被认可.
- 了解儿童炎症性肠病 (IBD) 和刺激性肠综合征 (IBS) 中的ANS参与对于全面的患者护理至关重要.
研究的目的:
- 调查和比较主观和客观的自主神经系统 (ANS) 异常在IBD和IBS儿童与健康儿童 (HC).
- 评估ANS功能障碍对这些儿科患者健康相关生活质量 (HRQoL) 的影响.
主要方法:
- 评估了69名儿童 (23名IBD,28名IBS,18名HC) 的队列.
- 使用复合自主症状评分 (COMPASS-31) 测量自主症状.
- 自主功能严重程度通过复合自主严重程度量表 (CASS) 进行评估,包括上腺体,心血管和运动指数. 儿科生活质量库存 (PedsQL) 测量了HRQoL.
主要成果:
- 患有IBS的儿童报告自主性症状负担最高 (COMPASS-31分数),其次是IBD患者和HC患者.
- 虽然整体CASS分数没有显著差异,但患有IBD的儿童表现出更大的气运动功能障碍.
- 与HC (7.1%) 相比,有症状的自主功能障碍在患有IBS (61.5%) 和IBD (42.1%) 的儿童中明显更为普遍.
结论:
- 自主神经系统 (ANS) 在儿科IBD和IBS中经常受到影响.
- 患有IBS的儿童经历了更大的自主症状负担,而患有IBD的儿童表现出更明显的气运动功能障碍.
- 观察到的ANS变化显著影响IBD和IBS儿童的与健康相关的生活质量 (HRQoL).
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