评估乳腺癌患者在进行 antracycline 治疗后左心房张力变化
Mostafa El Mokadem1, Saeed M Shaaban2, Osama Ahmed Amin3
1Department of Cardiology, Faculty of Medicine, Beni-Suef University, Mohamed Hasen Street, Beni-Suef, 62511, Egypt. mostafa.elmokadem9@gamil.com.
概括
乳腺癌的 antracycline 化疗后左心房压力 (LAS) 降低,表明早期心脏毒性. ангиотензин转化酶抑制剂可以减轻这些心脏变化.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 乳腺癌是女性主要的恶性瘤,用 antracyclines 治疗.
- 抗环素化疗可以导致亚临床心脏功能障碍.
- 左心房应变 (LAS) 是早期心脏毒性的潜在标志物.
研究的目的:
- 评估乳腺癌患者在以人环素为基础的治疗前和后LAS的变化.
- 评估LAS作为化疗诱导心脏毒性的早期指标.
主要方法:
- 120名侵袭性乳腺癌患者 (I-III阶段) 的前性观察队列研究.
- 治疗方案:多克索鲁比加环胺每三周进行3-4个周期.
- 在基线和每次化疗周期后进行心声成像以测量LAS.
主要成果:
- 在化学治疗后,LAS的测量显著下降.
- 降低LAS与左心室全球纵向应变正相关.
- 接受血管激素转化酶抑制剂 (ACEI) 的患者表现出较低的LAS变化率.
结论:
- 左心房应变在安环素治疗后恶化.
- 拉斯作为早期化疗诱导心脏毒性的预测剂.
- 在接受 antracycline 治疗的患者中,ACEI 可能具有心脏保护作用.
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