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Updated: May 20, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

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与PCSK9的E498A和R499G变体之间的LDL受体相互作用的结构动态

Nur Alya Amirah Azhar1, Yung-An Chua2,3, Hapizah Nawawi2,3

  • 1Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia.

Journal of molecular modeling
|May 19, 2025
PubMed
概括

分子动力学模拟揭示了蛋白转化酶Subtilisin/Kexin type-9 (PCSK9) 结合如何影响低密度脂蛋白受体 (LDLR) 结构. 在FH患者中发现的PCSK9变体E498A和R499G改变了LDLR动态和结合亲和力,影响胆固醇水平.

关键词:
家庭性高胆固醇血症 (FH)低密度脂蛋白胆固醇 (LDL-C) 是一种低密度脂蛋白胆固醇.低密度脂蛋白受体 (LDLR) 是一种分子动力学 (MD) 模拟蛋白转化酶亚提利辛/凯类型-9 (PCSK9)

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