在小鼠的早期发育中暴露于甲会破坏甲状腺,肝脏和丸的发育
Kyle Bouten1, Roman Parpart1, Marielle Calanza1
1Minnesota State University, Department of Biological Sciences, 242 Trafton Science Center South Mankato, Mankato, MN 56001, USA.
Integrative and comparative biology
|May 19, 2025
概括
在小鼠中暴露于甲酸盐会导致甲状腺变化,肝硬化,脏变化和丸损伤. 卵巢没有受到影响,与鱼类模型有一些相似之处和差异.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 哺乳动物毒理学
背景情况:
- 甲酸盐是一种内分泌干扰化合物 (EDC),存在于饮用水和食物中.
- 它抑制的吸收,减少甲状腺激素的合成.
- 甲酸对哺乳动物器官的影响比鱼类了解得更少.
研究的目的:
- 研究环境相关的甲酸盐度对小鼠甲状腺,肝脏,脏,丸和卵巢的形态影响.
- 将酸盐对哺乳动物的影响与现有的鱼类模型数据进行比较.
主要方法:
- 从受孕到产后85天,小鼠被暴露在0,10或100ppm的甲中.
- 目标器官 (甲状腺,肝脏,脏,丸,卵巢) 被剖析,染色和组织学检查.
- 形态变化被评估使用血素和色素染色.
主要成果:
- 甲酸暴露导致甲状腺合体面积减少,卵泡密度增加,血管生成和脂质积累.
- 肝脏显示增加了膨胀的肝细胞和脂质积累.
- 脏表现出脏管道厚度的改变,丸表现出无组织的精子管道,增加了莱迪格细胞面积和扩大的血管.
- 在卵巢中没有观察到任何显著的影响.
结论:
- 暴露于甲酸盐会导致小鼠甲状腺,肝脏,脏和丸的显著形态变化.
- 这些发现突出了哺乳动物和鱼类模型之间的酸盐作用的相似性和差异.
- 需要进一步的研究,以了解物种特异性对甲酸盐暴露的反应.
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