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Updated: May 21, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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点击构建的模块化信号吸收器嵌合体使膜蛋白的受体独立降解成为可能

Wanlin Xie1,2, Weidi Sun2, Qin Li2,3

  • 1School of Materials Science and Engineering, Tianjin University, Tianjin 300350, China.

Proceedings of the National Academy of Sciences of the United States of America
|May 19, 2025
PubMed
概括

这项研究引入了一种针对细胞膜蛋白的光体降解的新型信号光体平台 (SApt),克服了潜在的癌症治疗目前光体向仿真体 (LYTAC) 的局限性.

关键词:
它们是Aptamers.溶酶体准受体的受体膜蛋白质是一种膜蛋白质.分类信号信号的分类信号.

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