临床试验可访问性实用指南:使试验参与成为护理标准
Hedyeh Ebrahimi1, Jodie Allen2, Yelak Biru3
1Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA.
概括
癌症患者进入临床试验受到各种障碍的阻碍. 解决这些问题需要患者倡导者,瘤学家和行业的共同努力,以改善试验设计并减少癌症护理中的不平等.
科学领域:
- 在瘤学瘤学.
- 临床试验设计 临床试验设计
- 健康 公平 卫生 公平
背景情况:
- 临床试验对于推进癌症治疗至关重要,但面临着重大可访问性问题.
- 结构性,社会经济和系统性障碍限制了患者参与临床试验.
- 多学科的利益相关者确定了关键挑战,并提出了改善试验准入的解决方案.
研究的目的:
- 为改善临床试验可访问性的挑战和解决方案提供协作概述.
- 综合来自患者倡导,社区瘤学,工业和学术医学的观点.
- 倡导对临床试验设计进行现代化,并减少进入障碍.
主要方法:
- 综合利益相关者的观点的多学科视角作品.
- 分析挑战,包括语言障碍,财务毒性,代表性不足,基础设施限制和试验复杂性.
- 提出实际解决方案,如社区参与,资格改革,分散的试验和包容性设计策略.
主要成果:
- 患者倡导者强调社区参与和以患者为中心的设计,以解决代表性不足和财务毒性问题.
- 社区瘤学家呼吁改革资格和合作模式,以克服基础设施和实践负担.
- 工业和学术瘤学家提出了包容性设计,协议简化和务实试验方法的策略.
结论:
- 改善临床试验的可访问性需要所有参与癌症护理的部门共同承担责任.
- 现代化试验设计和减少障碍对于公平参与至关重要.
- 参与临床试验应该成为所有患者癌症护理的标准和可访问的组成部分.
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