脚亲感和与帕金森病硬度的关系
Jacquelyn V L Sertic1, Jason Kang2, Colum D MacKinnon3
1Brains in Motion Laboratory, Department of Family Medicine and Community Health, University of Minnesota, United States; Center for Clinical Movement Science, University of Minnesota, United States; Center for Applied and Translational Sensory Science, University of Minnesota, United States.
概括
患有帕金森病的人 (PD) 脚位置感受减少,这是自感的一个关键方面. 这种降低的自感敏度与PD患者下肢刚度的增加有关.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 临床神经学 临床神经学
背景情况:
- 由机械感受器附属体介导的自身感知对于身体位置感知和肌肉调节至关重要.
- 帕金森病 (PD) 的特点是自身感知功能障碍,影响运动控制.
- 了解PD中的脚自感受缺陷对于解决运动症状至关重要.
研究的目的:
- 测量帕金森病患者的脚位置感觉功能障碍.
- 调查脚亲感缺陷和PD肌肉刚性之间的关系.
- 阐明自身感知处理障碍在PD中的作用.
主要方法:
- 一个心理物理范式评估了脚位置感觉敏度,使用只是可察觉差异 (JND) 值和不确定性区域 (UA).
- 16名PD患者和16名对照参与了被动脚旋转任务.
- 肌肉刚性使用MDS-UPDRS III尺度进行评估.
主要成果:
- 与对照组相比,患有PD的个体表现出明显升高的JND值和UA (p < 0.05).
- 在JND值和下肢刚性之间发现了正相关性 (p = 0.047).
- 这些发现表明PD中脚自感敏度降低.
结论:
- 帕金森病会损害脚位置的感觉敏度.
- 降低自身感知敏度与增加的刚性有关,这表明PD中更广泛的自身感知处理变化.
- 自身感知处理缺陷有助于帕金森病的感觉和运动障碍.
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