用于生物医学应用的功能化珀石聚合物的合成,表征和抗菌活性
Deemah M Alenazy1, Nasser A Alamrani2, Nada Alkhathami2
1Department of Chemistry, College of Science, Northern Border University, P.O. Box.1321, Arar 91431, Saudi Arabia.
概括
改性聚合物,珀石-NH2和珀石-SO3H,有效地去除血中毒素,如肌氨酸和希普酸. 这些新材料还表现出显著的抗菌活性,为先进的血液透析过器铺平了道路.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 化学工程是化学工程的重要组成部分.
背景情况:
- 慢性病导致血中毒素的积累,如肌氨酸和希普酸.
- 开发有效的血液排毒方法对于患者的健康至关重要.
- 吸附材料的表面修饰为增强毒素去除提供了一个有希望的策略.
研究的目的:
- 合成和描述用于血液排毒的新型聚合物吸附剂.
- 调查改性珀石对肌素和希普酸的吸附能力和选择性.
- 评估合成材料的抗菌活性,以便在血液透析过器中潜在使用.
主要方法:
- 珀石聚合物与氨基 (AM-NH2) 和硫酸盐 (AM-SO3H) 基团进行了功能化.
- 用FT-IR,SEM,EDX和元素分析 (CHNS) 来进行材料的表征.
- 吸附动力学和平衡被用伪第一阶,伪第二阶,弗洛伊德利希和兰格穆尔模型研究.
主要成果:
- 与未经修改的珀石相比,AM-NH2和AM-SO3H显著提高了希普酸和肌素的吸附能力.
- AM-NH2对酸具有更高的选择性,而AM-SO3H对肌素具有更高的选择性.
- 合成的聚合物对大肠杆菌,金黄色杆菌和黑色杆菌表现出强大的抗菌活性,与商业抗生素相当.
结论:
- 功能化的珀石聚合物是主要血液毒素的有效吸附剂.
- 开发的材料具有显著的抗微生物特性,适合用于血液透析应用.
- 这项研究为抗微生物血液排毒过器提供了具有成本效益和环保的基础.
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