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在结性脊柱炎中的硬质素:一个元分析

Li-Wei Jiang¹, Mei-Ling Yuan¹, Li-Na Jiang¹

¹Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.

Clinica chimica acta; international journal of clinical chemistry

|May 19, 2025

概括

在结性脊髓炎 (AS) 患者和健康人群中,循环硬质素水平并没有显著差异. 然而,硬质可能表明AS患者的疾病活性,炎症和进展.

科学领域:

类风湿病学类风湿病学
生物化学生物化学
医学研究医学研究

背景情况:

化脊柱炎 (AS) 是一种慢性炎症性疾病,影响脊柱.
斯克莱洛斯是一种参与骨代谢的蛋白质,其在AS中的作用正在研究中.

研究的目的:

评估患有结性脊髓炎 (AS) 的患者的循环硬质素水平.
探索硬质素水平与疾病特征之间的潜在相关性.

主要方法:

在多个数据库 (PubMed,Embase等) 中进行了系统的文献搜索. 在2024年8月之前.
使用随机效应模型计算循环硬质素水平的标准化平均差异 (SMD) 和95%置信区间 (CI).
使用埃格尔线性回归测试评估了出版偏差,并进行了灵敏度分析.

主要成果:

分析了22项涉及1354名AS患者和871名对照者的研究.
在AS患者和正常对照者之间没有发现循环硬质素水平的显著差异 (SMD = -0.03,P = 0.92).
亚组分析表明,在特定地区,研究类型和患者组中,患病活性得分较低 (BASDAI,BASFI),CRP较低和特定成像得分 (mSASSS) 的患者群体中,硬质素水平较低.

结论:

在AS患者和健康对照者之间,循环中的硬质素水平没有显著差异.
诸如地理区域,研究设计,疾病活性 (BASDAI,BASFI),炎症 (CRP) 和成像分数 (mSASSS) 等因素会影响AS中的硬质素水平.
斯克莱洛斯可能成为评估AS疾病活性,功能状态,炎症和放射性进展的生物标志物.

关键词:

结性脊柱炎是一种疾病.疾病活动疾病活动进行元分析分析.斯克莱洛斯在其中.在Wnt/β-catenin信号通路中.

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