TEAD在神经祖先血统的进展过程中切换交互的合作伙伴来执行不同的功能
Charles H Perry1, Alfonso Lavado1,2, Venkata Thulabandu1
1Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Genes & development
|May 19, 2025
概括
TEAD转录因子与YAP/TAZ一起调节大脑发育. 与YAP/TAZ不同,TEAD1/2通过抑制Notch信号和与INSM1合作,促进神经前体进展,在神经发育中显示保留的功能.
科学领域:
- 发展生物学 发展生物学
- 神经科学是一个神经科学.
- 分子生物学分子生物学
背景情况:
- 转录因子的TEAD家族是Hippo途径中关键的DNA结合因子,与YAP/TAZ联合激活剂相互作用.
- 虽然河马通路至关重要,但哺乳动物中TEAD转录因子的体内功能在很大程度上仍未被描述.
研究的目的:
- 阐明TEAD1和TEAD2在哺乳动物神经发育中的体内功能.
- 为了比较TEAD1/2的功能与腹腔大脑中YAP/TAZ的功能.
主要方法:
- 对缺少TEAD1/2的小鼠突变体与YAP/TAZ进行比较分析.
- 研究神经上皮层结和祖先血统的进展.
- 检查TEAD1/2在Notch信号和INSM1合作中的作用.
主要成果:
- TEAD1/2和YAP/TAZ损失同样会破坏神经上皮细胞的顶端结.
- YAP/TAZ的损失会耗尽早期的祖先,增加后来的祖先,而TEAD1/2的损失会扩大早期的祖先,减少后来的祖先.
- TEAD1/2促进神经前代血统的进展,部分是通过抑制Notch信号和与INSM1合作.
结论:
- TEAD1/2在腹部脑部发育过程中具有YAP/TAZ依赖和独立的功能.
- TEAD1/2在促进神经祖先系的进展方面发挥着独特而至关重要的作用.
- 在神经发育中TEAD和INSM1的合作功能在元动物中被进化保存.
关键词:
角的原始原始体基底性腺 (Basal Ganglia) 是一个基本原始原始体的祖先它们是中间的祖先.内部神经元 内部神经元中间质突出 (MGE)神经发生神经发生.辐射性质细胞亚皮性原始原始体这里是subpallium的底层.更多相关视频
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