阶段调制以增加离子吞吐量用于离子移动性-飞行时间实验
Nathan W Buzitis1, Daniel Wu1, Zackary Kinlein1
1Department of Chemistry, Washington State University, Pullman, Washington 99164, United States.
概括
阶段离子移动性光谱学通过增加工作周期的10倍,大大缩短了分析时间. 这种无损离子操纵 (SLIM) 结构的进步提高了效率,而不损失分离功率.
科学领域:
- 分析化学 分析化学
- 物理化学 物理化学
- 频谱测量是一种光谱测量.
背景情况:
- 无损离子操纵结构 (SLIM) 提供先进的离子分离.
- 传统的SLIM方法通常具有有限的工作周期,影响分析吞吐量.
- 整合SLIM与飞行时间质量分析仪对于全面分析至关重要.
研究的目的:
- 为SLIM实施和评估一个基于阶段的门户计划.
- 提高SLIM实验的分析效率和工作周期.
- 评估分阶段封锁对分离能力和分辨能力的影响.
主要方法:
- 为离子操纵开发基于阶段的关方案.
- 阶段关门系统与6米SLIM设备和飞行时间质量分析仪的集成.
- 阶段离子运动谱与信号平均 SLIM 实验的比较.
主要成果:
- 与信号平均 SLIM 相比,相位离子流动性光谱学实现了 10 倍的工作周期的增加.
- 分离能力和分辨能力在分阶段模式下保持不变.
- 该方法允许代数或直接确定到达时间的整数.
结论:
- 基于阶段的门将显著提高SLIM的工作周期和离子效率.
- 这种方法可以减少实验分析的持续时间,而不会影响分离.
- 该方法可以很容易地集成到现有的离子流动性质谱仪器.
相关概念视频
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The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
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01:21Tandem Mass Spectrometry
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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and signal-to-noise ratio for the analyte. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.
Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called collision-induced...
Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called collision-induced...
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