在患有复发性或转移性HNSCCCC的患者中,外围乙氨基酸和免疫治疗反应
Yuexiang Qin1,2, Shanhu Yao3,4,5, Huimei Huang6
1Department of Health Management Medicine, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Scientific reports
|May 19, 2025
概括
较低的乙氨基酸水平 (绝对乙氨基酸计数和乙氨基酸百分比) 预测了脑皮细胞癌患者更好的免疫检查点抑制剂 (ICI) 反应和生存率.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 生物标志物研究 生物标志物研究
背景情况:
- 免疫检查点抑制剂 (ICI) 为复发性或转移性头支状细胞癌 (R/M HNSCC) 提供了新的治疗途径.
- 预测生物标志物对于优化R/M HNSCC中的ICI治疗疗效至关重要.
研究的目的:
- 调查绝对乙酸细胞计数 (AEC) 和乙酸细胞百分比 (EOS%) 与接受ICI的R/M HNSCC患者的治疗结果之间的关联.
- 确定AEC和EOS%是否可以作为ICI反应和生存的预测生物标志物.
主要方法:
- 74名R/M HNSCC患者的回顾性分析,这些患者接受了ICI治疗.
- 评估基线特征,瘤特异性,免疫相关不良事件,AEC和EOS%.
- 响应率的后勤回归,Kaplan-Meier曲线和Cox模型用于生存分析.
主要成果:
- 与较高水平相比,较低的AEC和EOS%与较高的ICI反应率 (分别为44.07%和47.17%) 有关.
- 较低AEC和EOS%的患者显示平均整体存活时间明显长 (22.63和22.07个月).
- 低AEC和EOS%独立与改善的生存率相关.
结论:
- 较低的AEC和EOS%独立地与使用ICI治疗的R/M HNSCC患者的更好的生存结果有关.
- 在R/M HNSCC中,AEC和EOS%显示出作为ICI治疗疗效的预测生物标志物的潜力.
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