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由于光照和二氧化的辐射而改变平板电脑的颜色:使用增塑剂预防变色
Yuki Matsushima1, Reo Kainuma2, Hidemasa Katsumi3
1Towa Pharmaceutical Co., Ltd., Kadoma, Osaka, 571-0033, Japan. y-matsushima@towayakuhin.co.jp.
AAPS PharmSciTech
|May 19, 2025
概括
由光和TiO2引起的药物片的变色可以防止. 特定的增塑剂,三乙酸和甘三酸,增强涂层强度,保持平板电脑的颜色和完整性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 摄影化学的使用.
背景情况:
- 平板电脑的颜色和形状对于品牌和防伪至关重要.
- 暴露于光线会导致平板电脑涂层中的基甲基纤维素 (HPMC) 降解,由二氧化 (TiO2) 触发.
研究的目的:
- 为了确定药物辅助剂,以防止TiO2介导的HPMC涂层薄膜因光引起的变色.
- 了解辅助剂抑制光化学降解的机制.
主要方法:
- 选各种制药辅助剂,以检测它们对照射下药片涂层颜色稳定性的影响.
- 评估涂层薄膜的物理性能,包括拉伸强度和玻璃过渡温度,在选定的辅助剂的存在下.
主要成果:
- 被认定为增塑剂的三乙酸和甘三酸有效地防止了药片中因光引起的颜色变化.
- 保护效应与涂层薄膜抗拉强度的增加相关.
- 没有发现与涂层薄膜的玻璃状或状状态有显著的相关性.
结论:
- 由于TiO2而引起的药物片的光变色可以通过添加特定的辅助剂来减轻.
- 增强涂层薄膜机械强度的助剂是防止光化学降解和保持平板电脑外观的关键.
- 使用塑化剂,如三乙酸和甘油三酸盐提供了一个可行的策略,以改善平板电脑的稳定性.
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