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准染色体重塑剂BAZ2B可以减轻肝脏衰老和MASH纤维化

Chuantao Tu1, Cheng Qian2, Shuyu Li3

  • 1Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. tuchuantao@shaphc.org.

Nature aging
|May 19, 2025
PubMed
概括

肝脏衰老加速了与代谢功能障碍相关的脂肪肝炎 (MASH) 纤维化. 准染色体重塑剂BAZ2B,可以保持脂质代谢,减少肝细胞衰老和MASH纤维化.

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...