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支气管喘中EOS计数和血清VEGF的诊断值及其与炎症因素和肺功能指标的相关性
Longqun Liu1, Chenfei Zhang2, Jian Xu3
1Department of Respiratory and Critical Care Medicine, The 904 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Wuxi, 214000, Jiangsu, China.
BMC pulmonary medicine
|May 19, 2025
概括
直接乙素 (EOS) 数量和血管内皮生长因子 (VEGF) 水平与支气管喘 (BA) 中的炎症和肺功能相关. 联合检测EOS和VEGF有助于诊断BA并评估其严重程度.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 临床免疫学临床免疫学
- 生物标志物发现发现
背景情况:
- 支气管喘 (BA) 的诊断和严重程度评估依赖于各种指标.
- 乙素 (EOS) 和血管内皮生长因子 (VEGF) 涉及喘病理生理学.
- 了解它们与炎症标志物一起的诊断价值至关重要.
研究的目的:
- 在支气管喘 (BA) 中评估直接乙素 (EOS) 计数和血清血管内皮生长因子 (VEGF) 的诊断效用.
- 评估EOS和VEGF与BA患者的炎症因素和肺功能指标的相关性.
- 为了确定 BA 的 EOS 和 VEGF 的联合诊断值及其严重程度.
主要方法:
- 追溯分析66名BA患者 (轻度,中度,重度) 和60名健康对照.
- 测量EOS计数,血清VEGF,炎症标志物 (IL-6,IL-7,IL-10) 和肺功能 (FEV1%,FEV1/FVC). 测量EOS计数,血清VEGF,炎症标志物 (IL-6,IL-7,IL-10) 和肺功能 (FEV1%,FEV1/FVC). 测量EOS计数,血清VEGF,炎症标志物 (IL-6,IL-7,IL-10) 和肺功能 (FEV1%,FEV1/FVC) 的测量.
- 使用了斯皮尔曼相关性和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 与对照组相比,BA患者的EOS,VEGF,IL-6,IL-7和IL-10,FEV1%,FEV1/FVC都较高,IL-7也较低.
- 较高的EOS和VEGF水平与喘严重程度的增加相关.
- 结合EOS和VEGF检测表明,与单个标志物相比,BA和其严重程度的诊断准确度更高.
结论:
- 在BA中,EOS数量和血清VEGF与炎症标志物和肺功能有显著的相关性.
- 对EOS计数和血清VEGF的综合评估为临床诊断和喘疾病分期提供了有价值的指导.
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