慢性乙型肝炎病毒感染患者的复发风险因素,这些患者通过以基化干扰素α-2b为基础的治疗实现功能治愈:一个多中心试点研究
Li-Jun Chang1, Chun-Qiu Hao2, Gui-Rong Rao3
1Department of Infectious Diseases, Yuncheng Central Hospital Affiliated to Shanxi Medical University, 3690 Hedong East Rd, Yuncheng, Shanxi Province, 044000, China.
Virology journal
|May 19, 2025
概括
在慢性乙型肝炎的PEG-IFN-α-2b治疗后,乙型肝炎表面抗原 (HBsAg) 的复发率为15.84%. 在实现功能治愈的患者中,抗HBs的存在显著降低了复发风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性乙型肝炎病毒 (HBV) 感染管理的目标是乙型肝炎表面抗原 (HBsAg) 清除.
- 基化干扰素-α (PEG-IFN-α) 的清除率高于核类型的HBsAg.
- 影响HBsAg治疗后复发的因素需要进一步阐明.
研究的目的:
- 评估使用PEG-IFN-α-2b实现功能治愈的慢性HBV患者HBsAg复发的风险因素.
- 在停止PEG-IFN-α-2b治疗后确定HBsAg复发的预测因子.
主要方法:
- 在101名慢性HBV患者接受PEG-IFN-α-2b治疗的多中心回顾性研究中.
- 患者实现了HBV DNA阴性和HBsAg清除,治疗后进行了≥48周的随访.
- 后勤回归分析了人口统计,病毒学,血清学和生物化学数据.
主要成果:
- 在平均70周的随访后,在16名患者中观察到15.84%的累积HBsAg复发率.
- 停药时血小板数量较高和巩固时间较短与复发风险增加有关.
- 抗HBs血清转换在所有时间点都大大降低了HBsAg复发风险.
结论:
- 在慢性HBV中使用PEG-IFN-α-2b的功能治愈与15.84%的HBsAg复发率有关.
- 抗HBs的发展是防止HBsAg复发的关键保护因素.
- 在研究期间,没有发生HBV DNA反弹或末期肝病.
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