特洛伊木马:纳米药物的秘密路线
Zoya Amin Khaskheli1, Daniya Nadeem1, Huzaifa Shakeel1
1Department of Pharmaceutics, Salim Habib University, Karachi 74900 Sindh, Pakistan.
Current pharmaceutical biotechnology
|May 20, 2025
概括
本综述探讨了纳米粒子药物输送的特洛伊木马策略,增强治疗剂的运输到目标地点. 它强调了纳米医学在癌症治疗中的应用,使用各种平台,如脂质体和细胞外囊泡.
科学领域:
- 纳米技术纳米技术
- 制药科学 制药科学
- 在瘤学瘤学.
背景情况:
- 纳米粒子对于药物输送具有多样性,使治疗剂的封装和运输成为可能.
- 纳米医学为治疗各种疾病提供先进的药物输送系统.
- 特洛伊木马战略是有针对性的药物输送的一个关键方法.
研究的目的:
- 为提供纳米粒子药物输送中特洛伊木马战略的全面审查.
- 讨论纳米药在癌症治疗中的应用.
- 探索用于癌症治疗的各种纳米医学平台.
主要方法:
- 对纳米粒子药物输送现有文献的系统审查.
- 分析特洛伊木马战略的有效性和可靠性.
- 检查不同的纳米医学平台 (脂质体,纳米颗粒等). 在癌症治疗中.
主要成果:
- 特洛伊木马战略使得药物能够高效,可靠地到达目标地点.
- 纳米药物在向癌症治疗方面显示出显著的前景.
- 包括脂质体,纳米颗粒和细胞外囊泡在内的各种平台是有效的特洛伊木马.
结论:
- 基于纳米粒子的特洛伊木马策略对于先进的药物输送至关重要.
- 对纳米医学平台的进一步研究可以优化癌症治疗.
- 未来的建议集中在应用纳米技术在制药领域.
相关概念视频
01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
339
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
339
01:22Drug Delivery: Miscellaneous Routes
295
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
295
01:24Cellular Membranes and Drug Transport
249
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
249
01:18Drug Delivery: Enteral Route
358
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
358
01:16Drug Delivery: Overview
267
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
267
01:29Drug Delivery: Parenteral Route
353
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
353