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Updated: May 21, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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B-9-8,一个新的哈曼·迪默,逆转ABCG2介导的化疗药物耐药性

Ruiqiang Zhao1,2, Yan Wen3, Chao-Yun Cai1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, USA.

Recent patents on anti-cancer drug discovery
|May 20, 2025
PubMed
概括

一种新型的哈曼二次体,B-9-8,通过抑制ABCG2载体,有效地逆转多药性耐药性 (MDR). 这种化合物增强化疗敏感性,没有毒性,提供了对抗癌症药物耐药性的有希望的策略.

关键词:
第111章 这是一件好事4-b]英多尔-9-yl) 坦 (B-9-8) 的使用.5-bis (1-甲基-9H-化物) [3-甲基-9H-化物]在ABC输送子家族G成员2 (ABCG2) 中.酸结合盒 (ABC) 载体传送器这就是Dimer Dimer的意思.哈曼·哈曼 (Harman Harman) 是一个著名的艺术家.多药性耐药性 (MDR) 是一种多药性耐药性.这是一种β-卡尔博林 (β-carboline).

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