肝脏作为日常代谢交叉谈话的联系点
Christopher Litwin1, Kevin B Koronowski1
1Department of Biochemistry & Structural Biology, University of Texas Health San Antonio, San Antonio, TX, United States; Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, United States.
International review of cell and molecular biology
|May 20, 2025
概括
生物钟通过协调能量摄入和消耗来维持新陈代谢平衡. 这个系统的干扰,特别是涉及肝脏相互作用的干扰,会增加代谢疾病的风险.
科学领域:
- 代谢调节 代谢调节 代谢调节
- 时间生物学 时间生物学
- 系统生物学 系统生物学
背景情况:
- 昼夜时钟通过将能量摄入和消耗与营养物质的可用性保持一致来协调日常代谢平衡.
- 哺乳动物的中央和外围时钟控制着食行为,神经系统活动和局部基因表达.
- 昼夜节律的破坏与代谢疾病的风险增加有关.
研究的目的:
- 审查肝脏和其他关键代谢组织之间的时空相互作用.
- 强调器官间沟通在昼夜新陈代谢中的作用.
- 为了强调现代生活方式的破坏对代谢健康的影响.
主要方法:
- 审查关于昼夜新陈代谢和器官间交叉通话的现有文献.
- 专注于代谢物交换,信号因子和荷尔蒙控制.
- 检查肝脏和骨肌肉,胰腺,肠道,微生物组和脂肪组织之间的相互作用.
主要成果:
- 肝脏作为一个中心的代谢枢纽,整合系统能量恒温.
- 时空相互作用,包括代谢物交换和激素信号传递,对于昼夜代谢控制至关重要.
- 由轮班工作和社会时差等因素引起的循环节障碍对代谢健康构成重大挑战.
结论:
- 了解对新陈代谢平衡的时钟控制机制至关重要.
- 器官间的交互,特别是涉及到肝脏,对于昼夜代谢调节至关重要.
- 需要有针对性的疗法来解决由昼夜干扰引起的代谢功能障碍.
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