Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

164
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
164
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Efficacy and safety of oral propranolol combined with intralesional injection of lauromacrogol for infantile hemangioma: a systematic review and meta-analysis.

Translational pediatrics·2026
Same author

Effect of Precompression on Detonation Performance and Products of Energetic Materials: Application to CL-20.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026
Same author

VEGFR2 inhibition potentiates STING-mediated antitumor immunity.

Cell reports·2026
Same author

Lineage-specific type 1 fimbriae in hypervirulent ST23 Klebsiella pneumoniae target α3β1 integrin to promote intestinal epithelial invasion.

BMC microbiology·2026
Same author

CogniSNN: Enabling neuron-expandability, pathway-reusability, and dynamic-configurability in spiking neural networks.

Neural networks : the official journal of the International Neural Network Society·2026
Same author

In Situ Engineered "Cascade-Amplified" Drug-Loaded Vesicles for Enhanced Cancer Stem Cell Therapy.

Journal of extracellular vesicles·2026

相关实验视频

Updated: May 5, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

17.0K

工程设计的多域脂质纳米颗粒用于有针对性的输送.

Zhaoyu Liu1,2, Jingxun Chen1,2, Mingkun Xu3

  • 1Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, 999077, China. aaron.ho@cuhk.edu.hk.

Chemical Society reviews
|May 20, 2025
PubMed
概括

工程化脂质纳米粒子 (LNP) 为癌症等疾病提供精确的药物输送. 一个新的框架分析了跨结构,表面,有效载荷和环境的LNP设计,以优化治疗性能.

更多相关视频

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.5K
Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

22.7K

相关实验视频

Last Updated: May 5, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

17.0K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.5K
Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

22.7K

科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术 纳米技术
  • 药物输送系统 药物输送系统

背景情况:

  • 工程化脂质纳米颗粒 (LNP) 对于复杂疾病的向药物输送至关重要.
  • 优化LNP设计面临各种准策略和生物障碍的挑战.

研究的目的:

  • 介绍一个多领域的框架来剖析和分析工程脂质纳米粒子 (LNPs).
  • 提供LNP工程,功能,表征和体内命运的全面概述.
  • 探索与外体和替代输送路径的比较.

主要方法:

  • 一个四个领域的框架 (结构,表面,有效载荷,环境) 用于LNP分析.
  • 审查当前和新兴的表征技术,包括冷TEM,分子动力学和人工智能应用.
  • 检查主动,被动,内源和刺激响应的准机制.

主要成果:

  • 该框架有助于对LNP工程挑战,机制和表征进行分析.
  • 突出了AI在LNP结构选和de novo设计中的潜力.
  • 展示了综合准机制如何提高可编程交付.

结论:

  • 多域框架为理解和优化工程LNP提供了一种系统的方法.
  • 工程LNP在治疗结果方面显示出超越生物复杂性的前景.
  • 未来的方向包括利用人工智能用于先进的LNP设计和应用.