关于巴西鱼类中毒和毒素毒性的全面概述
Mônica Lopes-Ferreira1, Felipe Justiniano Pinto1, Yasmin Stefanie Oliveira Costa1
1Immunoregulation Unit, Laboratory of Applied Toxinology (CAT/CeTICS-FAPESP), Butantan Institute, São Paulo, SP, Brazil.
概括
巴西有毒鱼类中毒事件的报道不足. 鱼毒液 (Thalassophryne nattereri) 是最有毒的,而鱼,子鱼和鱼毒液表现出多种影响,影响公共健康.
科学领域:
- 海洋生物学 海洋生物学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 巴西有各种各样的有毒鱼类,有着独特的毒素成分.
- 毒病例报告不足,阻碍了公共卫生政策的制定.
- 临床上有意义的物种包括刺鱼,鱼,鱼和鱼.
研究的目的:
- 为了比较医学上相关的巴西有毒鱼的毒性活动.
- 了解鱼毒的生物化学和毒理学特征.
主要方法:
- 在巴西对有毒鱼类事故进行了全面的文献搜索.
- 来自关键物种的毒素的生物化学和毒理学评估.
主要成果:
- 毒素在小鼠中表现出局部毒性的层次结构,与毒素多样性有关.
- 塔拉索弗林纳特雷里毒液显示出最高的毒性,导致严重的局部反应.
- 波塔莫特里贡 (Potamotrygon) orbignyi,Cathorops spixii和Pseudoplatystoma fasciatum的毒素引起了中等程度的反应.
- 斯科尔帕纳 (Scorpena plumieri) 的毒液诱导了中等程度的胀,但没有恶感或亡.
- 由P. orbigny,C. spixii和S. plumieri引起的毒害涉及具有血液溶解,蛋白溶解和脂酶活性的蛋白质.
- T. nattereri和P. fasciatum的毒素含有更广泛的毒素家族.
结论:
- 了解鱼毒活动对于开发抗毒疗法至关重要.
- 对毒鱼的进一步研究对于巴西的公共卫生管理至关重要.
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