在重复植入失败的妇女中,新鲜与冷胚胎移植
Saeideh Dashti1, Sahereh Arabian2, Robab Davar1
1Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi, University of Medical Sciences, Yazd, Iran.
Advanced biomedical research
|May 20, 2025
概括
与新鲜胚胎移植 (ET) 相比,冷胚胎移植 (FET) 在经历反复植入失败 (RIF) 的女性中显示出更好的怀孕率. 这表明FET可能是RIF患者更有效的策略.
科学领域:
- 生殖医学 生殖医学
- 不孕症研究 不孕症研究
- 胚胎移植技术 胚胎移植技术
背景情况:
- 复发性植入失败 (RIF) 在辅助生殖技术中构成了重大挑战.
- 将新鲜胚胎移植 (ET) 和冷胚胎移植 (FET) 进行比较对于优化RIF患者的结果至关重要.
研究的目的:
- 在被诊断为RIF的妇女中,评估和比较新鲜ET与FET的疗效.
- 确定哪种胚胎移植方法在RIF患者中产生更好的怀孕和活产率.
主要方法:
- 一项回顾性队列研究分析了RIF.女性的498个周期 (80个新鲜ET,418个FET).
- 数据是在2020年2月至2023年2月期间在雅兹德生殖科学研究所收集的.
- 在新鲜和冷ET组之间比较了化学怀孕,临床怀孕和活产率.
主要成果:
- 冷ET周期导致化学怀孕率显著上升 (29.7%与13.8%,P=0.002).
- 在FET周期中,临床怀孕率也显著高于FET周期 (20.6%对10.0%,P=0.027).
- 虽然FET组的活产率较高 (8.7%与4.9%相比),但这种差异在统计学上并不显著 (P=0.127).
结论:
- 冷胚胎移植 (FET) 周期似乎与复发性植入失败 (RIF) 的女性妊娠率的改善有关.
- 这些发现表明,FET可能是一个更有利的方法来管理RIF.
- 进一步的研究可以探索潜在的机制,并优化RIF患者的FET协议.
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