在患有风湿性疾病的患者中对妊娠和胎儿并发症的队列研究
Shadan Tafreshian1, Masoumeh Salari2, Zahra Mirfeizi2
1Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of obstetrics and gynaecology of India
|May 20, 2025
概括
患有风湿性疾病 (RDs) 的妇女怀孕会导致严重的孕产妇和胎儿并发症,包括高流产率. 系统性红斑狼 (SLE) 和血管炎是不良结果的关键风险因素.
科学领域:
- 产科和妇科 产科和妇科
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 风湿性疾病 (RDs) 可以影响怀孕,对母亲和胎儿构成风险.
- 了解这些风险对于有效管理和改善结果至关重要.
研究的目的:
- 调查由类风湿性疾病影响的怀孕中产妇和胎儿并发症.
- 为了确定与这群人群中不良妊娠结果相关的风险因素.
主要方法:
- 一项队列研究评估了241名在401个怀孕期间 (2016-2021) 患有RD的241名妇女.
- 收集的数据包括临床病史,怀孕细节,药物和免疫学标记.
- 对不利结果的风险评估使用了二进制物流回归.
主要成果:
- 该研究观察到38.2%的流产率和56.9%的活产率.
- 孕妇的并发症包括妊娠高血压和糖尿病;胎儿问题包括低出生体重,早产和心脏阻塞.
- 胎儿不良结果的关键风险因素包括全身性红斑狼 (SLE),血管炎,SLE/Sjögren综合征重叠和甲状腺功能低下症.
结论:
- 风湿性疾病会对怀孕结果产生负面影响,增加孕产妇和胎儿的并发症.
- 在怀孕期间有效管理RDS,特别是SLE和血管炎,至关重要.
- 建议采用多学科方法,早期识别风险和个性化治疗,以改善妊娠成功.
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