回到了正常状态? 一项关于刺激测试和内分泌诊断在COVID-19大流行之前,期间和之后的回顾性研究
Martina Peinkhofer1, Sofia Passarella1, Paolo Dalena1,2
1University of Trieste, Trieste, Italy.
Frontiers in endocrinology
|May 20, 2025
概括
COVID-19大流行改变了儿科内分泌学诊断,增加了中部早期青春期 (CPP) 诊断,同时减少了生长激素缺乏症 (GHD) 评估. 流行病后的趋势表明,人们正在回到流行病前的诊断模式.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- COVID-19大流行严重扰乱了全球医疗保健系统,影响了例行医疗咨询和诊断程序.
- 儿科内分泌学服务经历了显著的转变,包括转诊模式和诊断重点的变化.
研究的目的:
- 通过检查刺激测试,患者转诊和诊断的趋势,分析COVID-19大流行对儿科内分泌学的影响.
- 评估疫情期间和之后对中心早期青春期 (CPP) 和生长激素缺乏症 (GHD) 等疾病的评估的变化.
主要方法:
- 进行了一项回顾性研究,分析了从2019年到2023年在一个机构对1042名患者进行的1,526次刺激测试.
- 数据被分为流行病前,流行病和流行病后阶段,以比较诊断趋势.
主要成果:
- 虽然每天的测试量保持稳定,但GHD的氨酸刺激测试 (ATT) 的频率下降,CPP的LHRH测试 (LHRHT) 在大流行期间增加.
- 对GHD和CPP的诊断率保持稳定,但在大流行期间,被诊断患有CPP的女性比例大幅上升.
- 在流行后,CPP测试下降,GHD测试恢复到流行前的水平,这表明诊断延迟的解决方案.
结论:
- 疫情暂时改变了儿科内分泌学的诊断模式,GHD评估减少,可能是由于获得医疗保健的限制.
- 慢性肺炎诊断的暂时激增,特别是在女性中,可能与流行病相关的生活方式变化有关,流行病后趋势趋于正常化.
- 这项研究强调了大流行期间GHD发病率的独特变化,之前没有报告记录了类似的变化.
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