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睡眠时间对冠状动脉疾病患者的影响:为期四年的观察性研究
Runfeng Ma1, Ruoyu Wang1, Bingqian Wang1
1International Medical College, Chongqing Medical University, Chongqing, China.
Frontiers in endocrinology
|May 20, 2025
概括
短时间或长时间的睡眠增加了冠状动脉疾病 (CAD) 患者的心脏死亡风险. 短暂的睡眠也会在这个人群中增加心肌梗塞的风险.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 冠状动脉疾病 (CAD) 是全球主要的死亡原因.
- 了解中国西南地区CAD患者与睡眠时间相关的结果至关重要.
- 之前的研究还没有充分详细说明睡眠时间与该地区CAD结果之间的关联.
研究的目的:
- 研究冠状动脉疾病 (CAD) 患者不同睡眠时间和不良心血管结果之间的关联.
- 分析短 (<6小时) 和长 (>8小时) 睡眠时间与6-8小时相比对心肌梗塞和CAD相关死亡率的影响.
- 为西南中国队列提供关于睡眠时间在心血管健康中的作用的数据.
主要方法:
- 在中国西南地区,对816名CAD患者进行了长达四年的随访.
- 患者被分为三个睡眠时间组:<6小时,6-8小时和>8小时.
- 使用Fine-Gray模型,Kaplan-Meier估计和Cox回归来评估新发性心肌梗塞和CAD相关死亡等结果.
主要成果:
- 睡眠时间短 (<6小时) 与心肌梗塞风险增加2.67倍,与CAD相关死亡风险增加5.20倍有关.
- 长时间睡眠 (>8小时) 显示,与CAD相关的死亡风险增加了5.02倍.
- 这些关联在不同的统计模型中是一致的,包括细灰模型.
结论:
- 睡眠时间短 (<6小时) 和长 (>8小时) 都是CAD患者心脏病死亡的重要风险因素.
- 睡眠时间短暂也与中国西南地区CAD患者心肌梗塞风险增加有关.
- 睡眠时间应被认为是管理CAD患者的可修改因素.
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