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Updated: May 22, 2025

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
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Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

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DRBP-EDP:使用ESM-2和双路神经网络对DNA结合蛋白和RNA结合蛋白进行分类

Qiang Mu1,2, Guoping Yu2,3, Guomin Zhou1,2,4

  • 1Agricultural Information Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

NAR genomics and bioinformatics
|May 20, 2025
PubMed
概括

本研究介绍了DRBP-EDP,这是一种用于有效分类核酸结合蛋白 (NABPs) 的深度学习模型. 它准确地区分了DNA结合蛋白 (DBPs),RNA结合蛋白 (RBPs) 和非NABPs.

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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