相关实验视频

Updated: May 22, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

肺微生物组的改变与非小细胞肺癌中的免疫失衡相关

Jiuling Cheng¹, Huaqi Wang¹

¹Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Frontiers in immunology

|May 20, 2025

概括

肺微生物不平衡与非小细胞肺癌 (NSCLC) 的免疫变化有关. 增加的Prevotella和Veillonella与较高的炎症和较低的CD8+T细胞相关,影响预后.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

在非小细胞肺癌 (NSCLC) 中,肺微生物群失调和免疫功能障碍之间的关系需要进一步澄清.
了解这种联系对于制定疾病监测和预后预测策略至关重要.

研究的目的:

调查NSCLC患者肺部微生物组成变化与免疫系统状态之间的关联.
探索潜在的微生物生物标志物用于疾病进展和患者的结果.

主要方法:

16S rRNA测序用于分析NSCLC患者瘤和健康肺组织中的肺微生物群落.
评估了微生物丰富度,瘤特征 (阶段,转移,Ki-67) 和免疫标记物 (SII,T细胞子集) 之间的相关性.

主要成果:

在患有瘤的肺部和健康的肺部之间发现了微生物多样性的显著差异.
在NSCLC肺部中,Prevotella和Veillonella增加,而Pseudomonas和Staphylococcus减少.
升高的Veillonella与晚期NSCLC (IIIB-IV) 和更高的Ki-67水平相关. 增加的Prevotella和Veillonella丰度与更高的全身免疫炎症指数 (SII) 和降低的CD8+T细胞水平有关.

结论:

在NSCLC患者中,肺微生物组的组成发生了显著的变化.
特定的细菌Prevotella和Veillonella与NSCLC的免疫失调和疾病进展有关.
这些发现凸显了瘤相关微生物群作为生物标志物的潜力,用于监测NSCLC的进展和指导治疗决策.

关键词:

CD8 + T 细胞细胞组普雷沃特拉 (Prevotella) 在投票中表示支持.维隆内拉 (Veillonella) 是一种的植物.肺部的微生物群.非小细胞肺癌的肺癌.系统性免疫炎症指数

更多相关视频

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...