孕产后母亲的饮食模式与 orofacial 裂发生之间的关联
Erin G Sley1, Tania A Desrosiers1, Daniela Sotres-Alvarez2
1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
American journal of epidemiology
|May 20, 2025
概括
怀孕期间母亲的西方饮食与更高的口腔口腔裂 (OFC) 几率有关,包括口腔裂 (CL/P) 和口腔裂 (CP). 这项研究强调了孕产妇饮食对于预防出生缺陷的重要性.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 耳面裂 (OFC) 是一种常见的出生缺陷,已知风险因素有限.
- 以前对孕产妇饮食和OFC的研究往往集中在单个营养素上,使得饮食模式受到研究不足.
研究的目的:
- 调查孕期期间母亲的饮食模式与美国OFC的发生之间的联系.
- 确定特定的饮食模式,可能增加或降低带有/没有 palates (CL/P) 和 palates (CP) 的裂口唇的风险.
主要方法:
- 利用了来自国家出生缺陷预防研究 (1997-2011) 的数据,其中包括3,649例OFC病例和10,584例对照.
- 采用潜阶级分析来定义四种不同的母亲饮食模式:谨慎,西方,低热量西方和墨西哥.
- 应用后勤回归来计算每种饮食模式相关的OFC风险的调整几率比率 (aOR) 和95%置信区间 (CI).
主要成果:
- 西方饮食模式与CL/P (aOR: 1.3,95%CI: 1.2-1.5) 和CP (aOR: 1.2,95%CI: 1.1-1.4) 的几率增加有关.
- 低卡路里西方饮食与CL/P (aOR:1.2,95%CI:1.0-1.4) 显示出适度的关联,但没有CP (aOR:1.0,95%CI:0.9-1.2).
- 墨西哥的饮食与CL/P (aOR:1.1,95%CI:0.9-1.3) 和CP (aOR:0.8,95%CI:0.6-1.1) 都表现出较弱或无关联.
结论:
- 在孕期期间,母亲坚持西方饮食模式与更高的口腔口腔裂风险有关.
- 这些发现强调了孕产妇营养在OFC病因学中的关键作用,并表明需要进一步研究饮食干预措施.
- 与单个营养素方法相比,饮食模式分析可以更全面地了解母亲饮食对出生缺陷的影响.
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