对比诱导的急性损伤是由循环时钟/NRF2通路调节的
Shuqing Yang1,2, Xinxin Xu1, Lulu Wang1
1Center for Kidney Disease, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
IUBMB life
|May 20, 2025
概括
对比诱导的损伤显示出一天中的时间差异. 当在特定时间服用对比剂时,损伤更严重,这与昼夜节律和NRF2表达有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 时间生物学 时间生物学
- 生物化学 生物化学
背景情况:
- 功能,包括血液流动和过,表现出每天的昼夜节律.
- 急性损伤的发病和严重程度也显示昼夜模式.
- 对比介质是常见的,但它们对损伤时间的影响尚不清楚.
研究的目的:
- 调查对比引起的损伤 (CIKI) 的日间时间依赖性.
- 探索潜在的机制,包括铁和NRF2.2的昼夜调节.
主要方法:
- 对33名接受皮肤穿透冠状动脉血管造影的患者进行了回顾性分析.
- 在C57BL/6J小鼠中使用IOHEXOL在不同的昼夜时间 (ZT0和ZT12) 诱导损伤的实验.
- 评估损伤标志物 (NGAL,KIM1),脂质过氧化,铁和NRF2表达.
主要成果:
- 人类患者在早上 (6:0013:00) 服用对比剂时,血清NGAL的增加更明显.
- 与ZT0.0相比,在ZT12注射iohexol的小鼠表现出更严重的损伤,增加的管状铁亡和脂质过氧化.
- NRF2表达遵循由CLOCK调节的24小时昼夜节律;在ZT12减轻损伤时增加NRF2.
结论:
- CIKI表现出显著的日间时间变化.
- 受到CLOCK影响的NRF2的循环调节在CIKI易感性中起着至关重要的作用.
- 向铁和NRF2通路可能为CIKI提供治疗策略.
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