在中国的家禽中新出现的H3N3禽流感病毒的表征
Cheng Yan1, Jianzhong Shi1,2, Pengfei Cui1
1State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People's Republic of China.
Emerging microbes & infections
|May 20, 2025
概括
在家禽中发现了新的H3N3禽流感病毒. 这些重新组合的病毒显示出动物传播的潜力,突出显示了对动物群体中H3病毒的持续监测的需要.
科学领域:
- 兽医病毒学 兽医病毒学
- 公共卫生 病毒学 病毒学
- 动物传染病监测动物传染病监测
背景情况:
- 禽流感病毒 (AIV) 对家禽和人类健康构成持续威胁.
- 有效的动物疾病控制和流行病准备依赖于对新出现的AIV进行警监测和评估.
研究的目的:
- 为了检测和描述新型H3N3禽流感病毒.
- 评估这些病毒的起源,动物健康风险和动物感染潜力.
主要方法:
- 在2022年9月至2023年5月期间,对,子和的流感病毒进行常规监测和诊断.
- 基因分析以确定病毒的重新分类和起源.
- 在,小鼠和豚鼠中进行复制研究,包括传播实验.
主要成果:
- 在,子和子中发现了一系列重新分类的H3N3 AIV.
- 和子病毒含有来自H3N8和H10N3 AIV的基因;病毒是和野生鸟类病毒的重新分类.
- 病毒在器官中复制,与鸟类和人类受体结合,在小鼠中复制,并通过几内亚猪的呼吸道液滴传播,表明动物感染的潜力.
结论:
- 确定了具有复杂重组起源的新型H3N3 AIV.
- 这些病毒在哺乳动物模型中表现出复制和传播能力,这表明有动物性疾病的潜力.
- 对动物群体中H3 AIV的持续监测和控制对于公共卫生和动物疾病管理至关重要.
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