肺癌CT查计划中囊性肺病变恶性病变的风险
Suzanne C Byrne1,2, Andetta R Hunsaker1,2, Mark M Hammer1,2
1Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.
Radiology
|May 20, 2025
概括
囊性肺病变与结节壁加厚表明癌症风险较高. 没有加厚的单眼病变通常是良性的,大多数癌症是早期发现的.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 缺乏关于恶性瘤风险和囊性肺病变自然史的共识.
- 需要成像特征来评估肺癌查计划中的恶性瘤风险.
研究的目的:
- 评估在囊性肺病变中与恶性瘤风险相关的成像特征.
- 在肺癌查背景下分析这些病变的自然史.
主要方法:
- 对CT肺癌查检查的回顾性分析 (2015年1月 - 2023年7月).
- 对囊性病变的放射学报告的审查和对基线CT图像的分析,以观察形态和尺寸.
- 用卡普兰-梅尔曲线评估随访CT扫描病变变和分析癌症风险.
主要成果:
- 在15,762名患者中发现的235种囊性肺病变中,33个 (14%) 与肺癌有关.
- 结节壁加厚 (OR, 11) 和固体结节 (OR, 5.3),特别是有磨砂玻璃组成部分 (OR, 24),增加了癌症风险.
- 没有墙壁加厚的单眼病变 (n=46) 显示没有恶性病变. 随着时间的推移,损伤的生长/复杂性与恶性瘤风险相关 (P < .001).
结论:
- 囊性肺病变随着结节壁的加厚会增加恶性瘤的风险.
- 没有墙壁加厚的单眼囊病变具有最小的恶性瘤风险.
- 恶性囊性病变通常呈现缓慢生长,并在早期阶段 (0或I) 诊断出来.
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