牛皮关节炎发作发生率,定义和风险因素:系统性审查
Batoul Hojeij1, Gonul Hazal Koc1, Jolanda Luime1
1Department of Rheumatology, Erasmus Medical Center, Rotterdam, the Netherlands.
Rheumatology (Oxford, England)
|May 20, 2025
概括
牛皮关节炎 (PsA) 爆发的发病率为每年22% -23%,流行率为7% -10%. 目前的定义缺乏共识,需要一种标准化的方法来更好地管理和研究牛皮关节炎.
科学领域:
- 类风湿病学 类风湿病学
- 临床免疫学临床免疫学
- 流行病学 流行病学
背景情况:
- 牛皮关节炎 (PsA) 是一种慢性炎症性疾病.
- 疾病爆发严重影响患者的生活质量和治疗疗效.
- 了解爆发发病率,定义和风险因素对于最佳管理至关重要.
研究的目的:
- 系统地审查和综合有关牛皮关节炎的现有文献.
- 为了确定PsA爆发的发病率和流行率.
- 分析用于定义PsA爆发和相关风险因素的标准.
主要方法:
- 在Embase,Medline ALL,Web of Science和Cochrane Central进行全面的文献搜索,直到2023年9月.
- 包括54项研究 (队列,横截面,临床试验) 评估PsA爆发.
- 使用纽卡斯尔-太华尺度对包括的研究进行质量评估.
主要成果:
- 目前PSA爆发的发病率在7%-50%之间,高质量的研究表明7%-10%.
- 发病率各不相同:在6个月内为10-27%;在12个月内为22-23% .
- 爆发定义缺乏共识,经常使用疾病活动得分,患者/医生报告和治疗变化;风险因素证据有限.
结论:
- 根据高质量的数据,目前的PsA爆发率为7%-10%,每年发病率为22%-23%.
- 关于PsA爆发定义标准存在显著缺乏共识.
- 需要进一步的研究来建立标准化的定义,并确定PsA爆发的确定的风险因素.
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