艾利尔异硫酸对感染性病毒的抗病毒活性
Irene Falcó1,2, Gloria Sánchez3
1Department of Microbiology and Ecology, University of Valencia, Av. Dr. Moliner, 50., 46100, Burjassot, Valencia, Spain. irene.falcoferrando@usda.gov.
Food and environmental virology
|May 20, 2025
概括
酸 (AITC) 有效地减少肠道病毒,如甲型肝炎病毒 (HAV) 和诺罗病毒替代物. 这种天然化合物显示出对抗病毒污染的食物和表面消毒的潜力.
科学领域:
- 食品科学 食品科学 食品科学
- 病毒学 病毒学
- 微生物学 微生物学
背景情况:
- 肠道病毒,包括甲型肝炎病毒 (HAV) 和诺罗病毒,对公众健康构成重大风险.
- 有效的消毒策略对于预防病毒传播至关重要,特别是在食品安全方面.
研究的目的:
- 为了评估基异硫酸 (AITC) 对肠道病毒的抗病毒功效.
- 为了确定AITC度,温度和暴露时间对病毒无活化的影响.
- 评估AITC作为产品和与食品接触表面的天然消毒剂的潜力.
主要方法:
- 甲型肝炎病毒 (HAV) 和小鼠诺病毒 (MNV) 用AITC在不同度 (0.1%,0.5%),温度 (10°C,25°C,37°C) 和潜伏时间 (2小时,一夜之间) 治疗.
- 人类诺罗病毒 (HuNoV) 肠道悬浮被使用现场捕获定量逆转录聚合酶链反应 (RT-qPCR) 测试.
- 为了评估其作为消毒剂的有效性,AITC被应用于生产15分钟和30分钟.
主要成果:
- AITC证明了依赖于度,温度和时间的抗病毒作用.
- 观察到病毒标位显著降低,MNV下降3.75 log TCID50/mL,HAV在最佳条件下低于检测极限 (0.5%AITC,37°C,一夜之间).
- 在37°C时,AITC部分抑制了病毒囊及其对HuNoVs的受体之间的相互作用. 产品治疗没有显示病毒标位的显著变化.
结论:
- 酸 (AITC) 对肠道病毒,包括HAV和诺罗病毒表现出强大的抗病毒活性.
- 作为减少食品和食品接触表面的病毒污染的天然消毒剂,AITC显示出有前途,尽管需要进一步优化.
- 这些发现表明AITC在提高食品安全和预防病毒感染传播方面的潜在作用.
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