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Updated: May 23, 2025

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一种多形变异的ThPOK导致免疫的先天错误与T细胞缺陷和纤维化

Maryam Vaseghi-Shanjani1,2, Mehul Sharma2, Pariya Yousefi2

  • 1Experimental Medicine Program, Faculty of Medicine, The University of British Columbia , Vancouver, Canada.

The Journal of experimental medicine
|May 20, 2025
PubMed
概括

ThPOK基因中的一种新遗传变异导致一种罕见的人类疾病,影响T细胞发育和免疫功能. 这一发现突显了ThPOK在CD4+T细胞结合之外的关键作用,影响T细胞激活和纤维化通路.

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