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Updated: May 22, 2025

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
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MYC加IIa类HDAC抑制驱动非小细胞肺癌中线粒体功能障碍

Jina Park1, Ying-Yu Chen1, Jennie J Cao2

  • 1Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Cell reports
|May 20, 2025
PubMed
概括

结合MYC抑制剂与IIa类组素脱乙酶 (HDAC) 抑制剂,显示出治疗非小细胞肺癌 (NSCLC) 的前景. 这种双重向通过抑制MYC和增加线粒体反应性氧物种 (ROS) 来降低癌细胞活力.

关键词:
CP: 癌症 癌症 癌症我的世界 MYC在IIa类HDAC中.线粒体中的线粒体.非小型肺癌的肺癌.氧化状态 氧化状态

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