动脉是精细调节的热传感器,调节肌体调和血液流动
Thieu X Phan1,2, Niaz Sahibzada1, Marc Freichel3
1Department of Pharmacology and Physiology, Georgetown University, Washington DC 20007.
概括
组织温度显著影响血管肌原体度,动脉.
科学领域:
- 生理学 生理学 生理学
- 血管生物学 血管生物学
- 热调节 热调节 热调节
背景情况:
- 动脉通过肌体调节血流,稳定毛细血管压力.
- 组织温度是影响血液流动和血管导电性的已知因素.
研究的目的:
- 为了研究组织温度在调节血管肌原体度中的作用.
- 为了识别热敏离子通道参与热诱导的肌体色.
主要方法:
- 测量来自各种组织 (骨肌肉,肠道,大脑,皮肤) 的动脉中的肌体度,在不同的内压力和温度下.
- 对TRPV1和TRPM4通道进行药理和基因操纵.
- 对温度系数 (Q10) 和半最大响应温度的分析.
主要成果:
- 加热急剧激活了动脉中的肌原性音调,跨越多种组织,具有高温度系数 (Q10~11-20).
- 动脉热敏度是根据每个组织的不同静止温度调整的.
- TRPV1和TRPM4通道介导热诱导的肌性音调,具有明显的温度敏感性 (TRPV1的半最大响应在~31°C,TRPM4的半最大响应在~33°C).
结论:
- 热敏肌体度是一种关键的恒温机制,可以保护毛细血管完整性和液体平衡.
- 这种机制可以平衡温度引起的血液流动性和血管导电性的变化.
- 温度和内压力被独立感知并集成,以调节肌肉发作度.
相关概念视频
Autoregulation of Blood Flow
2.1K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
2.1K
Arteries and Arterioles
2.7K
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles...
2.7K
Neural Regulation of Blood Pressure
2.6K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.6K
Regulation of the Cardiovascular System
328
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
328
Thermosensation
30.3K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
30.3K
Blood Flow
65.5K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
65.5K


