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Updated: Jun 19, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

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在中,选小分子以通过调节由异体化诱导的形状变化来改变calpain蛋白解

Pitambar Poudel1, Ivan Shapovalov2,3, Shailesh Kumar Panday1

  • 1Department of Physics & Astronomy, College of Science, Clemson University, Clemson, South Carolina 29634, United States.

Journal of chemical information and modeling
|May 20, 2025
PubMed
概括

研究人员确定了调节calpain活动的小分子,这对于治疗疾病至关重要. 这些化合物向calpain-2催化 (CAPN2) 和调节 (CAPNS1) 子单元相互作用,揭示了治疗开发的新型全性机制.

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Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...