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Updated: Jun 13, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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功能丧失的Gαs罕见疾病变体对GPCR信号传递产生突变特异性影响

Theo Redfern-Nichols1, Shannon L O'Brien2,3, Xianglin Huang1

  • 1Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.

Science signaling
|May 20, 2025
PubMed
概括

与类型 Ic 伪偏偏甲状腺症相关的突变 Gαs 蛋白质 (L388R 和 E392K) 不同地破坏 G 蛋白结合受体 (GPCR) 信号传递. 了解这些特定的Gαs突变是开发针对这种罕见疾病的向治疗的关键.

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