非编码RNA赋予了学习和记忆的分子和细胞基质的作用
Alexander D Walsh1, Timothy W Bredy2
1UQ Centre for RNA in Neuroscience, Brisbane, QLD 4071, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4071, Australia; Peter Doherty Institute for Infection and Immunity, and Department of Infectious Diseases, University of Melbourne, Melbourne, VIC 3000, Australia.
Current opinion in neurobiology
|May 20, 2025
概括
大脑中的非编码RNA (ncRNA),包括长非编码RNA (lncRNA),圆形RNA (circRNA) 和微型RNA (miRNA),对于学习和记忆至关重要. 这些分子通过细胞内的精确相互作用来调节神经可塑性.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 非编码RNAs (ncRNAs) 在神经科学研究中获得了显著的关注.
- 新出现的证据强调了各种ncRNA类在大脑功能中的关键作用.
研究的目的:
- 讨论ncRNAs调节学习,记忆和神经可塑性的机制.
- 为提供参与这些过程的关键ncRNA类型的例子.
主要方法:
- 关于大脑中ncRNAs的最新科学文献的综述.
- 专注于作用机制,包括亚细胞局部化和分子相互作用.
- 讨论了长非编码RNAs (lncRNAs),圆形RNAs (circRNAs) 和微型RNAs (miRNAs) 的例子.
主要成果:
- ncRNAs,包括lncRNAs,circRNAs和miRNAs,是协调学习和记忆过程的组成部分.
- 这些分子通过精确的亚细胞定位来发挥它们的功能.
- 与DNA,mRNA和RNA结合蛋白的相互作用是关键的调节机制.
结论:
- ncRNAs在经验依赖的神经可塑性中发挥着根本性的作用.
- 了解ncRNA机制为学习和记忆提供了洞察力.
- 对ncRNA的进一步研究有望提高我们对大脑功能的了解.
相关概念视频
lncRNA - Long Non-coding RNAs
8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
Types of RNA
5.5K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.5K
Nucleic Acids
43.2K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
43.2K
Nucleic acids
157.7K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
157.7K
Ribosomal RNA Synthesis
13.0K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
13.0K
Nucleic Acid Structure
5.9K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
DNA Structure
DNA...
5.9K


