甲胺装载的Mn3O4@SiO2核心外纳米颗粒用于多种质母细胞瘤向治疗
Zahra Nozhat1, Abdul Wahab1, Asim Mushtaq2
1Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Colloids and surfaces. B, Biointerfaces
|May 20, 2025
概括
装有甲胺的新纳米颗粒通过穿越血脑屏障,有效地准质母细胞瘤 (GBM). 这些向的纳米颗粒显示了药物递送和疗效的增强,改善了GBM患者的治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 多形质母细胞瘤 (GBM) 的预后不好,原因是化学疗法药物通过血脑屏障 (BBB) 传递的挑战.
- 现有的GBM治疗疗法有效性有限,需要新的治疗策略.
- 纳米级生物材料为增强药物输送和BBB透提供了潜力.
研究的目的:
- 开发甲胺 (MET) 装载的Mn3O4@SiO2@cRGD纳米粒子 (MSMC NPs) 作为针对性,对pH响应的药物输送系统,用于GBM.
- 为了评估MSMCNP在体外治疗GBM的疗效.
- 探索MSMCNP作为精确癌症治疗的治疗平台的潜力.
主要方法:
- 合成和表征含有甲胺的Mn3O4@SiO2@cRGD纳米粒子 (MSMC NP).
- 细胞吸收的体外评估,不同pH值的药物释放动力学和U251和U87GBM细胞中的细胞毒性.
- 在3D球形模型中评估MSMCNP对细胞迁移的影响和亡诱导.
主要成果:
- 在MSMC NP中,药物负载能力高 (69.4%) 和封装效率高 (11.5%).
- 观察到细胞吸收增强 (2.5倍增加) 和pH响应的MET释放 (pH5.5时70%vspH7.4时30%).
- 与自由MET相比,MSMC NP显著降低了GBM细胞活力,抑制了细胞迁移 (80%),并增加了细胞亡 (40%在U251,35%在U87).
结论:
- MSMC NPs代表了一种有前途的向,pH响应的药物输送系统,用于GBM治疗.
- 开发的纳米粒子增强了整个BBB的药物输送,并提高了治疗疗效.
- 这项研究为基于Mn3O4的纳米药物在精确的癌症治疗中提供了基础.
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