由Pasteurella multocida引起的罕见婴儿败血症和脑膜炎:一个病例报告
Ming-Ming Ni1, Wen-Xin Lin2, Yang Li2
1Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Journal of infection and public health
|May 20, 2025
概括
在婴儿中,一种罕见的Pasteurella multocida脑膜炎病例被使用下一代测序 (NGS) 诊断出来. 这种先进的技术确定了抗生素耐药性,指导了对这种具有挑战性的感染的个性化治疗.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 基因组医学是基因组医学.
背景情况:
- 帕斯图雷拉多达是一种致动物性细菌,可以引起严重的感染.
- 脑膜炎和腹腔是严重的并发症,特别是在婴儿中.
- 早期和准确的诊断对于有效的治疗和改善结果至关重要.
相关概念视频
Atypical Pneumonia
88
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
88
Viral Meningitis
217
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
217
Bacterial Meningitis I: Introduction
31
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
31
Bacterial Meningitis II: Pathophysiology
45
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
45
Brain Abscess l: Introduction
47
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
47
Pneumonia I: Introduction
58
Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
58


