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Updated: May 22, 2025

Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
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通过IVT mRNA和融合蛋白技术增强GLP-1表达,用于糖尿病治疗

Xiaoying Wu1, Jingtao Qiao2, Fei Xiao3

  • 1Peking University Fifth School of Clinical Medicine, Beijing, China; Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing, China.

Journal of pharmaceutical sciences
|May 20, 2025
PubMed
概括

一种新的葡萄糖类-1-Fc (GLP-1-Fc) mRNA疗法在糖尿病管理方面显示出前景. 这种mRNA诱导持续的蛋白质生产,有效降低小鼠的血糖水平,没有观察到组织损伤.

关键词:
糖尿病 糖尿病 糖尿病聚变蛋白质的融合蛋白质是如何形成的类似于葡萄糖的-1在体外转录的mRNA.蛋白质替代疗法是一种蛋白质替代疗法.

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