生物电子鼻子用于通过脑电脑接口通过嗅觉灯泡电极阵列通过超追踪气味检测
Qian Lu1, Ming Yi2, Junjie Jiang1
1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Research Center for Brain-inspired Intelligence, Xi'an Jiaotong University, No.28, West Xianning Road, Xi'an, 710049, Shaanxi, PR China.
Biosensors & bioelectronics
|May 20, 2025
概括
这项研究开发了一个新的生物混合系统,使用实验室老鼠来检测超低度的危险化学物质. 该系统达到90%以上的准确性,为环境安全提供了电子鼻子的敏感替代方案.
科学领域:
- 神经科学是一个神经科学.
- 生物技术是生物技术.
- 环境科学 环境科学
背景情况:
- 检测危险的挥发性化合物对于公共卫生和环境安全至关重要.
- 像电子鼻子这样的传统方法在百万分之几 (ppm) 范围内具有检测极限.
- 许多有害物质在十亿分之一 (ppb) 度下是危险的,需要更敏感的检测方法.
研究的目的:
- 开发一种新的生物混合系统,用于超追踪检测危险的挥发性化合物.
- 为了利用哺乳动物嗅觉系统对化学传感的高度敏感性.
- 将行为调节与体内电生理学记录相结合,以提高检测能力.
主要方法:
- 操作人员对Rattus norvegicus (实验室老鼠) 进行调节,以识别TNT,TNP和ppb水平的气.
- 使用多通道电极阵列,从背部和腹部嗅球 (OB) 进行体内电生理学记录.
- 使用支持矢量机算法解码神经活动模式来分类气味的身份.
主要成果:
- 成功训练了老鼠在ppb度下检测目标气味.
- 来自OB的电生理学数据允许准确地分类气味的身份.
- 支持矢量机算法在基于神经活动的气味分类方面取得了超过90%的准确性.
结论:
- 开发的生物混合系统证明了使用脑计算机接口与嗅觉系统用于超标探测的可行性.
- 与现有的电子鼻子技术相比,这种方法提供了显著增强的灵敏度.
- 生物混合系统对高效的环境和生物医学传感应用具有前景.
相关概念视频
Gustation
43.5K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
43.5K
Olfaction
40.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
40.5K
G-Protein Gated Ion Channels
5.5K
GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
Sensory...
5.5K
Olfactory Receptors: Location and Structure
10.5K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.5K
Physiology of Smell and Olfactory Pathway
13.1K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
13.1K
Taste Buds and Receptors
5.6K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
5.6K


