在社区居民群体中,唾液pH值与估计的球过率状态之间的关联:横截面研究
Nephron
|May 20, 2025
概括
唾液pH与估计的淋巴细胞过率 (eGFR) 状态有关,为功能评估提供了血液尿素 (BUN) 的潜在替代方案. 这一发现可能有助于早期发现和监测慢性病 (CKD).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生物化学
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 是一个全球性健康问题,死亡率高.
- 早期发现CKD对于改善患者的治疗结果至关重要.
- 已知液pH值在衰竭中的变化,但其与估计的淋巴细胞过率 (eGFR) 的关联需要进一步研究.
研究的目的:
- 为了研究唾液pH和eGFR状态之间的关联.
- 开发和验证使用唾液pH的eGFR状态的预测模型.
- 为了比较基于唾液pH的模型与传统的血尿素 (BUN) 模型的预测准确度.
主要方法:
- 使用来自社区的队列数据 (2017-2019) 来自1,056名日本受试者的横截面研究.
- 开发了后勤回归模型:一个使用BUN,另一个用唾液pH取代BUN,结合人口和生活方式因素.
- 使用298名受试者的数据验证了模型的预测准确性.
主要成果:
- 骨和唾液pH都与eGFR状态显著相关 (P < 0.001).
- 唾液pH模型,包括年龄,病史和生活方式因素,表现出与BUN模型 (AUC 0.796与0.799,P = 0.933) 相比的准确性.
结论:
- 唾液pH与eGFR状态显著相关.
- 使用唾液pH的预测模型显示,用于评估功能,BUN的准确性与BUN相比较.
- 唾液pH值可以作为eGFR状态评估的非侵入性生物标志物.
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