在高风险高血压患者中,有氧性脂质失调和发生心血管事件
Richard Kazibwe1, Jeshuah Jehopio2, Christopher L Schaich3
1Department of Internal Medicine, Wake Forest University School of Medicine, 1 Medical Center Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Progress in cardiovascular diseases
|May 20, 2025
概括
以低HDL-C和高TG为特征的动脉性失脂症 (AD) 显著增加了高血压患者心血管疾病 (CVD) 的风险. 早期发现和治疗AD对于减少长期心血管疾病事件至关重要.
科学领域:
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
- 高血压管理 高血压管理
背景情况:
- 以低HDL-C和高TG来定义的动脉性脂质失调症 (AD) 是心血管疾病 (CVD) 的已知危险因素.
- 高血压管理策略旨在减轻心血管疾病风险,但阿尔茨海默病在这些治疗臂中的具体影响需要进一步阐明.
研究的目的:
- 为了评估甲基性脂质失调症 (AD) 和心血管疾病 (CVD) 风险之间的关联.
- 为了比较高血压患者的心血管疾病风险与AD在强化治疗下与标准静缩血压 (SBP) 降低治疗目标.
主要方法:
- 利用了来自于缩血压干预试验 (SPRINT) 9361名参与者的数据.
- 根据基线HDL-C和TG水平,将参与者分为四个脂质类别,AD定义为低HDL-C和高TG.
- 采用多变量考克斯回归来评估脂类和复合初级心血管疾病结局之间的关系.
主要成果:
- 与正常脂质样本相比,动脉性脂质不良症 (AD) 与主要心血管事件风险增加41% (HR: 1.41;95% CI: 1.12-1.77) 相关.
- 患有AD的个体在标准 (HR: 1.38) 和密集 (HR: 1.44) SBP降低组中都显示出心血管疾病风险升高.
- 与正常的HDL-C和TG (7.4%) 相比,患有AD的参与者中,初级心血管疾病事件的发生率更高 (9.5%).
结论:
- 动脉性失脂症 (AD) 与高血压个体心血管疾病 (CVD) 风险的增加有显著关联.
- 建议在高血压患者中及早发现AD,无论糖尿病状况如何,以加强治疗努力并降低长期心血管疾病风险.
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