氧化应激及其与不同精子质量组的精子参数的相关性
Maroua Ben Rhouma1, Hatem Bahri2, Mustapha Ben Khalifa3
1Research Laboratory of Integrated Physiology, Faculty of Science of Bizerte, University of Carthage, Bizerte, Tunisia.
Clinical and experimental reproductive medicine
|May 20, 2025
概括
氧化应激通过增加脂质过氧化和降低抗氧化酶活性,对男性生育能力产生负面影响. 针对氧化应激的干预措施可以改善不孕男性的精子质量.
科学领域:
- 生殖生物学 生殖生物学
- 安德罗学与人类学
- 生物化学 生物化学
背景情况:
- 男性不孕症影响了试图怀孕的夫妇的很大一部分.
- 氧化应激越来越被认为是导致男性生殖功能障碍的关键因素.
- 了解不孕男性氧化应激的具体机制对于开发有效的治疗方法至关重要.
研究的目的:
- 调查氧化应激标志物与不育男性的精子质量之间的关系.
- 评估脂质过氧化水平和精液中关键抗氧化酶的活性.
- 为了将氧化应激指标与特定的精液参数相关联.
主要方法:
- 163名不育男性被招募并根据精液质量进行分类.
- 精液分析包括精子度,运动性和形态学 (WHO指导方针).
- 氧化应激通过测量甲 (MDA) 和催化酶 (CAT),超氧化脱氧化酶 (SOD) 和谷氨过氧化酶 (GPx) 的活性来评估.
主要成果:
- 病理性精液组显示精子数量,运动性和形态显著减少.
- 在所有病理群体中都观察到高水平的甲 (MDA),表明脂质过氧化.
- 发现抗氧化酶 (CAT,SOD,GPx) 的活性下降,特别是在最严重的不孕症病例中.
结论:
- 高氧化应激和脂质过氧化与不育男性的精子质量差有很强的相关性.
- 降低抗氧化酶活性表明对氧化损伤的防御受损,导致精子功能障碍.
- 抗氧化剂疗法有可能改善受影响男性的精子质量和生育结果,这需要进一步研究.
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