核心等级5:证据评估间接性的评级确定性
Gordon Guyatt1,2,3, Alfonso Iorio4,2, Hans De Beer5
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada guyatt@mcmaster.ca.
概括
本文解释了在系统性审查和指南中评估证据的核心GRADE方法. 它详细说明了如何处理间接证据,比较研究PICO与目标PICO,在差异很大时降低确定性.
科学领域:
- 健康研究方法的方法论.
- 基于证据的实践实践.
背景情况:
- 系统性审查,临床指南和医疗技术评估依赖于强有力的证据评估.
- 建议评估,开发和评价 (GRADE) 框架的评级是这一过程中的一个关键工具.
- 处理间接证据对于准确的评估至关重要.
研究的目的:
- 介绍核心GRADE方法来评估证据,特别是间接证据.
- 为指导指南制定者和医疗技术评估从业人员评估证据确定性提供指导.
主要方法:
- 指定目标人群,干预,比较和结果 (PICO).
- 将目标PICO与现有研究的PICO进行比较.
- 判断当研究PICO与目标PICO不同时,效果大小存在实质差异的可能性.
主要成果:
- 当目标和研究PICOs显著不同时,研究提供间接证据.
- 间接性可能会导致证据确定性的评级下降.
- 效果大小存在实质差异的可能性会影响下调证据确定性的决定.
结论:
- 核心GRADE方法为处理间接证据提供了一个结构化的方法.
- 仔细的PICO规范和比较对于准确的证据评估至关重要.
- 对于间接性而言,Judicious的下调评级提高了推和评估的可靠性.
相关概念视频
Inductive Reasoning
59.8K
Inductive reasoning is a form of logical thinking that uses related observations to arrive at a general conclusion. It is uncertain and operates in degrees to which the conclusions are credible. As such, inductive arguments can be weak or strong, rather than valid or invalid, and conclusions can be used to formulate testable, falsifiable hypotheses.
Inductive reasoning is common in descriptive science. A life scientist makes observations and records them. This data can be qualitative or...
Inductive reasoning is common in descriptive science. A life scientist makes observations and records them. This data can be qualitative or...
59.8K
Deductive Reasoning
54.8K
Deductive reasoning, or deduction, is the type of logic used in hypothesis-based science. In deductive reasoning, the pattern of thinking moves in the opposite direction as compared to inductive reasoning, which means that it uses a general principle or law to predict specific results. From those general principles, a scientist can deduce and predict the specific results that would be valid as long as the general principles are valid.
For example, a researcher can deduce specific predictions...
For example, a researcher can deduce specific predictions...
54.8K
Critical Thinking II
2.7K
Critical thinking is a cognitive process with several attributes. The attributes of critical thinking include the following:
2.7K
Sieve Analysis and Grading Curves
280
Sieve analysis is a method used to determine the particle size distribution of aggregate materials. This process involves the following steps:
280
Types of Aggregate Grading
364
Aggregate grading is crucial in economically obtaining a concrete mix with adequate strength, reasonable workability, and minimal segregation. There are four types of aggregate gradation: well-graded, uniformly (or one-sized) graded, gap-graded, and open-graded.
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
364
Critical Thinking
64
Critical thinking involves reflective and productive thinking and the evaluation of evidence. Critical thinkers seek to understand the deeper meaning of ideas, question assumptions, and make independent decisions about what to believe or do. Scientists, for instance, are often critical thinkers. Critical thinking also requires humility about what we know and don't know and the motivation to look beyond the obvious. It is essential for effective problem-solving.
Colleges and universities are...
Colleges and universities are...
64

