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Updated: May 23, 2025

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
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Published on: July 29, 2022

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在帕金森病中,TREM2缺乏会通过加剧α-Synuclein诱导的溶酶体功能障碍来加剧认知障碍

Baoyu Zhu1,2, Jiezhu Feng1,2,3, Xiaomei Liang1,2

  • 1Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong Province, China.

Cell death discovery
|May 20, 2025
PubMed
概括

在帕金森病 (PD) 中,TREM2 缺乏会通过损害微质功能和α-synuclein 清除来加剧认知衰退. 这突出了TREM2作为PD相关认知障碍的潜在治疗标.

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