美国新墨西哥州发生了对多种药物耐药的Shigella flexneri疫情,影响了人类和非人类灵长类动物
Sarah Shrum Davis1,2,3, Paris Salazar-Hamm3,4,5,6, Karen Edge1
1Infectious Disease Epidemiology Bureau, New Mexico Department of Health, Santa Fe, NM, USA.
Nature communications
|May 20, 2025
概括
新墨西哥州的一次多抗药性Shigella flexneri疫情影响了人类和非人类灵长类动物,导致死亡. 基因组监测突出显示了一种健康方法中抗菌素耐药性的威胁.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 基因组监测 基因组监测
背景情况:
- 石菌是一种由石菌引起的胃肠道感染,它给公共卫生带来了挑战.
- 抗菌素耐药性在传染病爆发中越来越令人担忧.
- 人与动物之间病原体的动物传播是一种重大健康问题.
研究的目的:
- 为了调查在新墨西哥州阿尔伯克基发生的大规模Shigella flexneri血清型2a疫情.
- 分析来自人类和非人类灵长类动物种群的Shigella分离的基因组流行病学.
- 评估多药耐药性对治疗结果和公共健康的影响.
主要方法:
- 202个人类和4个非人类灵长类动物的全基因组测序来自新墨西哥州的Shigella flexneri分离物.
- 分析了来自其他州的15个密切相关的分离物.
- 流行病学数据收集和疫情影响人口的分析.
主要成果:
- 确定了一场涉及人类和非人类灵长类动物的多抗药性Shigella flexneri 2a的大型疫情.
- 证明了同一个S. flexneri菌株在人类和非人类灵长类动物群体之间的循环.
- 在人类中观察到高住院率 (近70%),其中有一例死亡,在非人类灵长类动物中观察到高发病率和六例死亡.
- 证实了多种药物耐药性,包括诺基诺隆耐药性,导致治疗失败.
结论:
- 该研究强调了抗微生物耐药生物对脆弱的人类和非人类灵长类动物种群的威胁.
- 基因组监测对于检测和应对传染病爆发在"一健康"框架内至关重要.
- 共享的西格拉菌株强调了人类和动物健康在传染病传播中的相互联系.
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