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Updated: May 23, 2025

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艾滋病毒状况改变了乳腺癌妇女的免疫细胞透和激活特征

Marcus Bauer^1,2, Pablo Santos³, Andreas Wilfer^4,5

¹Institute of Pathology, University Hospital Halle, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany. marcus.bauer@uk-halle.de.

Nature communications

|May 20, 2025

概括

由于瘤微环境的改变,感染艾滋病毒的妇女 (WLWH) 患乳腺癌的生存率较低. 在WLWH瘤中增加的CD8+T细胞和CD276表达可能会导致这种差异.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

与艾滋病毒阴性女性相比,感染艾滋病毒 (WLWH) 的妇女的乳腺癌 (BC) 死亡率更高.
免疫力在WLWH中发生变化,可能会影响癌症的进展和结果.

研究的目的:

为了研究黑人南非和纳米比亚BC患者的瘤微环境 (TME).
为了比较WLWH和HIV阴性女性之间的TME组件.
确定导致WLWH.中整体存活率 (OS) 较差的因素.

主要方法:

从296名黑人BC患者 (117名WLWH) 的瘤样本分析.
评估年龄,艾滋病毒状态,瘤阶段,激素受体,HER2状态和OS.
评估TME组件,包括CD8+和CD4+T细胞,CD276/B7-H3表达和IFN-γ信号.

主要成果:

无论病毒活动或免疫抑制,WLWH的生存期都显着较短.
与HIV阴性患者相比,在WLWH的TME中观察到CD8+ T细胞的增加.
在WLWH瘤中发现CD276/B7-H3表达升高和IFN-γ信号增强,独立于临床因素.

结论:

在WLWH的TME中改变的T细胞组成和CD276表达可能会导致乳腺癌存活率较低.
这些TME变化在WLWH中为新型治疗策略提供了潜在的目标.

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